Chinese Academy of Sciences Study on Nicotine Anti-aging Effect Muted

On March 2, ' Health Guide ' published an article in The People's Daily 'Heavy research by the Chinese Academy of Sciences said that Nicotine has an amazing anti-aging effect'. This paper cited the research paper 'Nicotine rebalances NAD + homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity' by Li Xiang's team from The Brain Cognition and Brain Disease Institute (BCBDI) of Shenzhen Institute of Advanced Technology of Chinese Academy of Sciences. This paper mainly focuses on the effect of Nicotine on the human anti-aging substance NAD + ( the oxidation form of nicotinamide adenine dinucleotide ). It preliminarily reveals the significant impact of Nicotine on NAMPT activity in mouse experiments.

'Health Guide ' borrows the words of tobacco control experts, "If you want to improve your physical health and really can't quit cigarettes, you can switch to e-cigarettes."  The platform of " Health Guide " (also known as " Shaanxi Health Guide " ) introduces " Health Guide " is a nationwide comprehensive service newspaper approved by the National Press and Publication Administration.

The Study: Nicotine Delays Age-related Deterioration and Cognitive Decline

By querying the above research papers mentioned on the official website of 'Nature Communications ', 2Firsts found that the abstract part is :

• NAD + imbalance is associated with aging and various diseases.
• Nicotine is a metabolite of the NAD + metabolic pathway, which has anti-inflammatory and neuroprotective effects, but its underlying molecular mechanism is still unclear.
• Due to the independence of nicotine acetylcholine receptors, low doses of Nicotine can restore the aging-related decline in NAMPT activity through SIRT1 binding and subsequent NAMPT deacetylation, thereby increasing NAD + synthesis.
• 18F-FDG PET imaging showed that Nicotine also effectively inhibited glucose metabolism in aging male mice.
• Nicotine improves cellular energy metabolism disorders and delays age-related deterioration and cognitive decline by promoting neuronal production, inhibiting neuroinflammation, and protecting organs from oxidative stress and telomere shortening.
• These findings provide mechanistic evidence that low-dose Nicotine can activate the NAD + rescue pathway and improve age-related symptoms.

Different "NATURE"

According to 2Firsts research, the publication published this paper differs from the well-known ' Nature', but its sub-published ' Nature Communications'. The two-year impact factor of ' Nature Communications ' is 17.694, while that of ' Nature ' is 69.504. 'Natural communication ' is less authoritative than 'Nature ' in academic research.

Research institutions cooperated with e-cigarette companies many times.

This research paper was published by the Li Xiang team of The Brain Cognition and Brain Disease Institute (BCBDI). It is affiliated with the Shenzhen Institute of Advanced Technology, which was established with the assistance of the Chinese Academy of Sciences, the Shenzhen Municipal Government, and the Chinese University of Hong Kong. Its official website states that SIAT aims to enhance the innovative capacity of the equipment manufacturing and service industries in the Guangdong-Hong Kong region, promote the development of emerging industries possessing their proprietary intellectual property, and become a world-class industrial research institute.

According to the 2Firsts inquiry, Shenzhen Advanced Institute has cooperated with at least two e-cigarette enterprises :

• Shenzhen First Union Technology Co., Ltd
  • In 2017, Shenzhen Advanced Institute cooperated with Shenzhen First Union Technology and established the first technology research institute in the industry.

• RELX Technology 
  • In May 2022, the scientific research team of Shenzhen Advanced Institute and RELX Technology jointly published a paper in the Chinese Journal of Drug Abuse Prevention and Treatment. According to the article, since 2019, Shenzhen Advanced Institute has carried out a series of scientific research cooperation with RELX.

Reference: 

[1] 深圳先进院李翔团队揭示低剂量尼古丁激活NAD+合成通路延缓衰老的机制

[2] 尼古丁通过增强 NAMPT 活性重新平衡 NAD +体内平衡并改善雄性小鼠的衰老相关症状

[3] 电子烟企业：深圳市合元科技有限公司

[4] RELX悦刻与中科院深圳先进院合作！首个研究成果竟是它

[5] SIATER说 | 楚明：“我在先进院平台上成长非常快”