The Controversy Surrounding Delta-8: Is it Safe?

Sep.02.2022
The Controversy Surrounding Delta-8: Is it Safe?
Delta-8 is a rising trend in the cannabis industry, but its safety is in question due to lack of regulation.

In recent years, you may have heard of Delta-8. From 2020 to 2021, searches for this term on Google increased by over 850%, particularly in states where recreational marijuana use is banned in the US. According to a recent study, 16% of frequent marijuana users also purchase delta-8 gummies.


Some people believe this is the next trend in cannabis products: it can legally provide comfort and alleviate pain without being too closely associated with drugs.


However, the FDA and the CDC recently issued warnings that Delta-8 is a potentially harmful drug that has been linked to thousands of poisoning incidents. Is this an example of excessive caution on the part of authorities? It depends on what substances the brands are adding to their Delta-8 products.


Early research suggests that Delta-8 may be milder than regular marijuana. However, due to the lack of regulation for this drug, most Delta-8 gummy products on the market differ from laboratory-tested items and may contain heavy metals and other cannabinoids. Therefore, some experts advise against using it.


What is Delta-8?


Technically speaking, Delta-8 refers to Delta-8-THC or T.H.C., the primary psychoactive component of cannabis. The most common T.H.C. found in the cannabis plant is Delta-9-THC, which has a molecular structure that is almost identical to Delta-8-THC. Because the molecules are so similar, Delta-8 and Delta-9 have similarly stimulating effects on the brain and are the reason behind the euphoric high people seek from cannabis use. Both compounds bind to receptors in the brain.


A study has shown that Delta-8 gummies have a milder effect compared to Delta-9 because of its weaker binding to CB1 receptors. According to Linda Klumpers, co-founder of pharmacology consulting company Verdient Science specializing in cannabis drugs, Delta-8-THC is less effective than Delta-9-THC.


Why do experts use it?


Delta-8 has received support from public opinion surveys, claiming that compared to Delta-9-THC, users experience less paranoia and anxiety. The most common effects of Delta-8 are stimulation, pain relief, and relaxation. However, users have also reported some issues, such as difficulty focusing attention, short-term memory problems, and altered sense of time.


According to Jessica Kruger, an assistant professor of clinical health behavior at the University at Buffalo, who supervised the study, participants reported that Delta-8 was not as potent as Delta-9 when they were asked to compare the two. They complained that when using Delta-9, they only wanted to lie on the couch or not do anything at all, but with Delta-8 they could still easily control their behavior.


According to the doctor, Delta-8 gummies are unlikely to produce different effects than Delta-9, possibly due to a lower amount of substances in the CB1 receptors.


Is Delta-8 legal?


One of the key appeals of Delta-8 to users is its alleged mildness, and the second is its legality.


CBD Gummies.


The 2018 Agriculture Act, which legalized marijuana, marks the beginning of the rise of Delta-8.


According to the Agricultural Act, as long as it contains less than 0.3% T.H.C., you can produce it legally. However, the author of the Act made a mistake as T.H.C. should be specifically described as Delta-9-THC, according to Kent Vrana, a pharmacology professor at Pennsylvania State University.


According to Eric Leas, an assistant professor of public health at the University of California, San Diego, "These producers think that since you can extract CBD from marijuana, and CBD is not T.H.C., it is still referred to as marijuana." In other words, delta-8 is chemically T.H.C., but it is still legal because it is considered marijuana.


Synthetic Delta-8-THC is typically sold legally through the internet and retailers, and is often added to candy and e-cigarettes. However, since these products are not regulated, there may be discrepancies between what is advertised on the label and what is actually in the packaging. This can include variances in the effects of Delta-8, as well as unexpected presence of other substances, such as Delta-9.


Is Delta-8 Dangerous?


Many public health experts are concerned about the lack of regulations in the United States regarding the purchase of Delta-8 gummies. Multiple investigations have revealed impurities and harmful substances in Delta-8 products, including one investigation conducted in the US. Additionally, all 27 products tested contained potentially harmful substances, likely stemming from the production process, such as heavy metals like lead and mercury and other cannabinoids like Delta-9-THC.


Dr. Vrana stated that although he did not believe delta-8 was inherently more harmful than delta-9, there are still many opportunities for error because it is unregulated. In September, the CDC issued health advisories regarding delta-8 due to these concerns. In May, the FDA also issued a warning after receiving 104 reports of adverse reactions related to delta-8, including potential side effects such as hallucinations, vomiting, trembling, anxiety, disorientation, confusion, and loss of consciousness.


Similarly, the National Poison Control Center received nearly 2,000 calls for help related to delta-8 between January 2021 and February 2022, with 41% of these calls involving young people accidentally consuming products containing delta-8. One of these incidents resulted in a fatal accident.


Result


If Delta-8 is used excessively, T.H.C. may lead to prolonged vomiting, mental illness, and addiction. Due to a lack of federal regulations, delta-8 and all other uncontrolled forms of T.H.C. (including delta-10) are banned in 14 states. This includes several places where recreational marijuana is legal, such as Colorado and New York.


Conclusion


According to every expert consulted, including those in favor of the legalization of marijuana, the consensus is that the safety of delta-8 products cannot be guaranteed. However, they also stated that even in this situation, it is not recommended to categorize all Delta-8 products as illegal.


Statement:


This article is compiled from third-party information and is intended solely for industry communication and learning.


This article does not represent the views of 2FIRSTS, and 2FIRSTS is unable to confirm the truthfulness and accuracy of the content. The compilation of this article is only intended for industry exchange and research purposes.


Due to limitations in translation skills, the compiled article may not express the same meaning as the original. Please refer to the original article for accuracy.


2FIRSTS maintains full alignment with the Chinese government regarding its statements and stance on any domestic, Hong Kong, Macau, Taiwan and foreign-related matters.


The compilation of this information is copyrighted by the original media and author. If there is any infringement, please contact us for removal.


This document has been generated through artificial intelligence translation and is provided solely for the purposes of industry discourse and learning. Please note that the intellectual property rights of the content belong to the original media source or author. Owing to certain limitations in the translation process, there may be discrepancies between the translated text and the original content. We recommend referring to the original source for complete accuracy. In case of any inaccuracies, we invite you to reach out to us with corrections. If you believe any content has infringed upon your rights, please contact us immediately for its removal.

Japan Tobacco International Malaysia Appoints Didier Ellena as Managing Director; Predecessor Reassigned to North Asia Role
Japan Tobacco International Malaysia Appoints Didier Ellena as Managing Director; Predecessor Reassigned to North Asia Role
Japan Tobacco International (JTI) Malaysia has appointed Didier Ellena as managing director, effective Jan 5. Ellena has spent more than 30 years with JTI and has held leadership roles across multiple countries and regions. His predecessor, Juliana Mohd Yahaya, will become vice president of sales and marketing for JTI North Asia.
Jan.15 by 2FIRSTS.ai
U.S. FDA Posts Final ZYN MRTP Materials, Sets March 4 Deadline for Public Comments
U.S. FDA Posts Final ZYN MRTP Materials, Sets March 4 Deadline for Public Comments
U.S. FDA has released the final batch of materials for ZYN MRTP applications and set March 4 (11:59 p.m. ET) as the deadline for public comments to be considered in the agency’s review.
Feb.03 by 2FIRSTS.ai
PMI Launches Mass Production of ZYN at $600M Aurora Manufacturing Hub
PMI Launches Mass Production of ZYN at $600M Aurora Manufacturing Hub
Philip Morris International (PMI), through its subsidiary Swedish Match, has started large-scale production at a 600,000-square-foot ZYN nicotine pouch facility in Aurora, Colorado. The $600 million investment makes the site one of three ZYN manufacturing plants in the United States and the company’s second U.S. facility after Owensboro, Kentucky.
PMI
Feb.21
China Tobacco Annual Meeting Flags “New Growth Drivers” for 2026: Cigarette Innovation, Domestic Cigars, Overseas Business and Multi-Purpose Use
China Tobacco Annual Meeting Flags “New Growth Drivers” for 2026: Cigarette Innovation, Domestic Cigars, Overseas Business and Multi-Purpose Use
China’s tobacco authorities used their annual industry meeting in Beijing to outline new growth drivers for 2026, highlighting cigarette innovation, domestic cigars, overseas business expansion and multi-purpose tobacco applications.
Special Report
Jan.20
Mexico City hands over 50,376 vapes and e-cigarettes for destruction, valued at USD 570,000
Mexico City hands over 50,376 vapes and e-cigarettes for destruction, valued at USD 570,000
Mexico City Head of Government Clara Brugada handed over 50,376 vapes and e-cigarettes in the Zócalo for final destruction. The report puts the value at 10 million pesos (about USD 570,000) and says the goods were seized from a stall and a warehouse in the Historic Center, with one person detained because selling these products is illegal.
Jan.19 by 2FIRSTS.ai
FDA Commissioner Stresses “Predictability” as Science Chief Addresses Industry Uncertainty
FDA Commissioner Stresses “Predictability” as Science Chief Addresses Industry Uncertainty
FDA Commissioner Marty Makary briefly appeared at the February 10 PMTA roundtable, underscoring the importance of regulatory predictability. At the close of the session, Office of Science Director Matthew Farrelly responded to industry concerns over review uncertainty, stating the agency will issue a written summary of feedback, while reiterating that no fixed quantitative risk benchmark governs authorization decisions.
Feb.11