Smoking is a major risk factor for many health conditions, including lung cancer and cardiovascular disease (CVD). Although nicotine replacement therapy (NRT) and behavioral encouragement are the most effective ways to quit smoking, the high relapse rate indicates the need to reconsider smoking cessation strategies.
For example, 27% of smokers interested in quitting use electronic cigarette products, while 18% use NRT. However, evidence regarding the impact of electronic cigarettes on cardiovascular health is limited. Therefore, this randomized controlled trial aims to compare the CVD outcomes of smokers randomly assigned to receive nicotine-containing electronic cigarettes, nicotine-free electronic cigarettes, or NRT treatment at 3 and 6 month follow-ups.
A study conducted on a group of 248 individuals who smoked at least 10 cigarettes a day and aimed to quit smoking measured cardiovascular disease (CVD) outcomes such as flow-mediated dilation (FMD), mean arterial pressure (MAP), and skin microvascular responses to acetylcholine (ACh) and nitroprusside (SNP). The study found that all three groups demonstrated improvement in FMD at 3 months (β=3.33, 95%CI 2.61-4.05, p = 0.0001) and 6 months (β=2.69, 95%CI 2.02-3.35, p < 0.0001). However, there were no significant differences in other CVD outcomes such as skin microvascular responses to ACh and SNP, and MAP between the three treatment groups. Overall, the study concludes that quitting smoking leads to improved CVD outcomes at 3 and 6 months, but there is no significant difference in improvement between the treatment groups.
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