E-cigarettes Show Lower Cell Toxicity Than Traditional Cigarettes

E-cigarettes Show Lower Cell Toxicity Than Traditional Cigarettes
The study found that e-cigarettes have less impact on cells than traditional cigarettes, using extracellular vesicle proteomics for analysis.

On November 5th, a research team led by Associate Researcher Yu Suhong from Fuzhou University published a paper in the authoritative global toxicology journal, "Toxicology in Vitro," which found that the impact of electronic cigarettes on cells is significantly lower than that of traditional cigarettes.

The study used exosome proteomics for the first time to compare the effects of electronic cigarettes and traditional cigarettes on human bronchial epithelial cells. Exosomes are small membrane vesicles containing complex RNA and proteins, which can be used as biomarkers for early diagnosis and prognosis evaluation of diseases such as cancer.

Research data shows that cigarette tar leads to more differences in protein expression of extracellular vesicles within cells, and these are significantly enriched in cancer signaling pathways. Meanwhile, differences caused by e-cigarettes are less pronounced. Toxicology studies have also found that cigarette tar significantly inhibits cell activity, while e-cigarette tar did not produce similar negative effects, indicating that the cellular toxicity of e-cigarettes is relatively low.

The paper was published in the toxicology SCI journal, "In Vivo Toxicology.

In recent years, several studies have found that electronic cigarettes may be a form of harm reduction product.

In 2021, the Pennsylvania State University College of Medicine published a paper in Cancer stating that e-cigarettes could be effective tools for quitting smoking and also decrease the production of carcinogens in smokers' lungs. In 2022, an editorial in Nature suggested that for patients with gum health concerns, e-cigarettes may be a safer nicotine substitute and could reduce the risk of oral cancer.

According to Associate Researcher Yu Suhong, this study is the first to systematically analyze the safety of cigarettes and e-cigarettes starting from extracellular vesicles, filling a gap in the relevant field.

According to research findings, electronic cigarettes are less harmful than traditional cigarettes and may be a reduced-harm product," said Yu Suhong. However, electronic cigarettes are not entirely safe and should not be used by non-smokers.

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