High Smoking Rates & Related Deaths in the US

Sep.06.2022
High smoking rates lead to addiction and health risks. Despite this, 22.3% of the global population still uses tobacco products.

A significant portion of the world's population are smokers. In fact, according to the World Health Organization's data, 22.3% of the global population use tobacco products. The main reason people smoke is to reduce stress, but it comes with the risk of addiction. This is because tobacco contains a chemical substance called nicotine, which creates a sense of relaxation when ingested.


Tobacco is one of the leading causes of death, with over 8 million deaths worldwide each year being attributed to tobacco use. It also increases the risk of various health issues such as stroke, cancer, and heart disease.


NiceRx has conducted a study on the countries and states with the highest smoking rates and the most deaths related to smoking in the year 2022.


The state with the highest smoking rate in the United States.


West Virginia state.


Smoking Rate in 2022: 23.8%


West Virginia, located in the southeastern region of the United States, is one of the smallest states with a population just exceeding 1.79 million, making it the twelfth least populous state. However, despite its small size, it has the highest smoking rate in the country, with a rate of 23.8%.


The smoking rate in Kentucky is projected to be 23.6% in 2022.


Kentucky borders West Virginia and is located in the southeastern United States. As of 2020, its population exceeded 4.5 million. Its smoking rate is comparable to West Virginia's, being only 0.2% lower.


Louisiana State


Smoking rate in 2022: 21.9%.


Louisiana, located in the southern region of the United States, is the 25th most populous state with a population of 4.65 million. As of 2022, Louisiana has a smoking rate of 21.9%, which is the third highest in the country.


Ohio State


Smoking rate in 2022: 20.8%


The Midwestern state of Ohio is the seventh most populous state in the United States, with a population just slightly below 11.8 million. As of 2022, Ohio has a smoking rate of 20.8% among its population, with over 2.4 million smokers.


Mississippi state


In 2022, the smoking rate in Mississippi, a state located in the southeastern region of the United States with a population of approximately 2.96 million and the lowest per capita income, ranks as the fifth highest in the country at 20.4%. This rate is almost three times that of Hawaii, which has one of the lowest smoking rates.


The state with the highest number of smoking-related deaths in the United States.


West Virginia.


Every year, 241 people die from smoking per 100,000 people.


West Virginia has the highest smoking rate in the United States, so it's not surprising that it also ranks highest in smoking-related deaths. This southeastern state reports 241 smoking-related deaths per 100,000 people annually.


In Kentucky, 197 people die annually from smoking per 100,000 individuals.


Despite West Virginia experiencing a population increase of over double, Kentucky comes in as a close second. High smoking rates often lead to an increased occurrence of smoking-related health issues. This has even resulted in the state seeing 197 deaths per 100,000 people annually.


Arkansas


192 people die each year from smoking per 100,000 individuals.


As the third largest state in the southern United States, Arkansas ranked sixth in smoking rates across the country in 2022. The state sees 192 smoking-related deaths per 100,000 residents each year, just slightly lower than Kentucky.


Oklahoma state.


188 people per 100,000 die every year due to smoking.


Oklahoma, located in the southern region of the United States and sharing its eastern border with Arkansas, has a smoking rate of 18.9% in 2022, ranking just outside the top ten highest smoking states. Despite this, the state still sees 188 smoking-related deaths per 100,000 people annually. Nevertheless, Oklahoma has been gradually tightening smoking laws, especially those targeting youth smoking.


5. Mississippi State


183 people die each year from smoking per 100,000 individuals.


To compile this data, NiceRX utilized the national rankings from the "World Population Review" and the state rankings from the "US World Population Review.


Statement


This article is compiled from information provided by a third party and is intended solely for the purpose of industry communication and learning.


This article does not represent the views of 2FIRSTS and 2FIRSTS cannot confirm the authenticity or accuracy of its content. The translation of this article is solely for industry exchange and research purposes.


Due to limitations in the translator's proficiency, the translated article may not fully reflect the original text. Please refer to the original article for accuracy.


2FIRSTS is fully aligned with the Chinese government in regards to any domestic, Hong Kong, Macau, Taiwan, or foreign related statements and positions.


The copyright of compiled information belongs to the original media and author. If there is any infringement, please contact us for deletion.



Disclaimer

This article is provided solely for professional research, industry discussion, and informational purposes. Any references to brands, companies, products, technologies, or policies are made for factual reporting and analytical purposes only, and do not constitute endorsement, recommendation, promotion, or advertising by 2Firsts.

Nicotine-containing products, including but not limited to cigarettes, e-cigarettes, heated tobacco products, and nicotine pouches, carry significant health risks. Readers are responsible for complying with all applicable laws and regulations in their respective jurisdictions, including age restrictions and access limitations.

The information contained in this article should not be regarded as investment, legal, medical, regulatory, or commercial advice. While 2Firsts strives to ensure the accuracy and reliability of its content, it does not assume liability for any direct or indirect loss arising from errors, omissions, inaccuracies, or reliance on the information contained herein.

This article is not intended for individuals below the legal age for accessing tobacco or nicotine-related information in their jurisdiction.

 

Copyright Notice

This article is either original content produced by 2Firsts or content reproduced, translated, summarized, or adapted from third-party sources with attribution where applicable. The intellectual property rights of the original content remain with 2Firsts or the respective original rights holders.

No individual or organization may copy, reproduce, distribute, republish, modify, translate, or otherwise use this content without prior authorization. Any unauthorized use may result in legal action.

For copyright-related inquiries, corrections, or removal requests, please contact: info@2firsts.com.

 

AI-Assisted Translation and Editing Notice

Portions of this article may have been translated, edited, or reviewed with the assistance of artificial intelligence tools to improve efficiency and readability. Due to the limitations of AI-assisted translation and editing, discrepancies, omissions, or inaccuracies may exist when compared with the original source.

Where applicable, readers are advised to refer to the original source for the most complete and accurate information. If you identify any errors or believe that any content infringes upon your rights, please contact us at info@2firsts.com, and we will review and address the matter promptly.

FDA Launches Elsa 4.0 and Completes HALO Data Platform Consolidation
FDA Launches Elsa 4.0 and Completes HALO Data Platform Consolidation
The U.S. Food and Drug Administration announced on May 6 that it has advanced its modernization initiative by launching Elsa 4.0, an upgraded internal AI tool, and consolidating more than 40 application and submission data sources, systems and portals into a new platform called HALO. FDA said the integration of HALO and Elsa will allow staff to query data and build workflows without manually uploading documents in each chat.
May.07 by 2FIRSTS.ai
FDA Expands ENDS Market Access With First Authorization of Non-Tobacco and Non-Menthol Products
FDA Expands ENDS Market Access With First Authorization of Non-Tobacco and Non-Menthol Products
The U.S. Food and Drug Administration (FDA) announced on May 5, 2026 that it authorized the marketing of four Glas electronic nicotine delivery system (ENDS) products through the premarket tobacco product application (PMTA) pathway. The authorized products are Classic Menthol, Fresh Menthol, Gold and Sapphire pods, each containing 50mg/ml, or 5%, tobacco-derived nicotine.
May.06 by 2FIRSTS.ai
RJR Vapor Loses Tax Refund Case as Texas High Court Finds VELO Pouches Taxable
RJR Vapor Loses Tax Refund Case as Texas High Court Finds VELO Pouches Taxable
The Texas Supreme Court issued a case summary on May 8, 2026, describing its decision in Hancock v. RJR Vapor Co. LLC. The dispute centered on whether RJR Vapor’s VELO oral nicotine pouches are taxable as “tobacco products” under the Texas Tax Code. Lower courts had held that the pouches were not taxable tobacco products, but the Texas Supreme Court reversed, concluding that VELO pouches are taxable because they are made of “a tobacco substitute.”
May.09 by 2FIRSTS.ai
Glas Says FDA Scientific Review Backed Several Flavored Products Before Senior Leaders Blocked Them
Glas Says FDA Scientific Review Backed Several Flavored Products Before Senior Leaders Blocked Them
Glas says newly released internal FDA records show agency scientific reviewers supported authorization for several flavored G2 products before senior leadership halted them. According to documents obtained through a Freedom of Information Act request, FDA’s Office of Science first recommended marketing authorization for all eight products in December 2025 and later supported six of them in February 2026. FDA ultimately authorized only the G2 device and one tobacco-flavored pod in March.
Apr.23 by 2FIRSTS.ai
 Philip Morris Lowers Profit Outlook as Zyn Faces Competition and FDA Delays
Philip Morris Lowers Profit Outlook as Zyn Faces Competition and FDA Delays
According to Reuters, Philip Morris International (PMI) lowered its 2026 adjusted earnings-per-share forecast amid regulatory uncertainty around Zyn nicotine pouches, rising competition and shipment pressure in the U.S. market.
PMI
Jun.02
Multi-State Coalition Urges F1 to End Nicotine Sponsorships, Citing Zyn and Velo
Multi-State Coalition Urges F1 to End Nicotine Sponsorships, Citing Zyn and Velo
Hawaii Attorney General Anne Lopez is co-leading a coalition of 19 states and jurisdictions urging the Fédération Internationale de l’Automobile (FIA) and Formula 1 to end sponsorships involving tobacco and nicotine products, including nicotine pouch brands such as Zyn and Velo.
News
Jun.09