A new in vitro study has shown that aerosols from nicotine electronic cigarettes do not produce the cellular effects caused by cigarette smoke, which can lead to blood vessel damage and a range of heart diseases. It also found that aerosols from heated tobacco products produce far fewer adverse cellular effects compared to cigarettes. This research is crucial as smokers are two to four times more likely to suffer from heart disease than non-smokers, and one-fifth of smoking-related deaths are caused by cardiovascular diseases.
However, the significance of this study published last month goes beyond these specific findings. It is part of a replication initiative aimed at replicating the most famous studies conducted by tobacco companies to independently evaluate their scientific validity. The replication project aims to replicate ten international scientific studies, comparing the toxicity levels of traditional cigarette smoke, e-cigarettes, and heated products using human cells. The replication project is working to replace junk science with reliable data.
The project is being operated by the Center of Excellence for the Acceleration of Harm Reduction (CoEHAR). The organization is headquartered in Sicily and has previously exposed deep methodological flaws in highly cited e-cigarette studies. It is now working to replace junk science with reliable data while recognizing that industry-funded research is often controlled by tobacco and ignored by broader public health organizations. Dr. Riccardo Polosa, founder of CoEHAR, told Filter: "By replicating the results of tobacco-funded research on e-cigarettes and heated tobacco products, we demonstrate that these results are reliable and trustworthy.
A new study conducted by an international research group affiliated with CoEHAR has been carried out in independent laboratories in Indonesia, Oman, Russia, Serbia, Greece, and the United States. This finding challenges the repeated claims by medical associations that using e-cigarettes or heated tobacco products is equally as dangerous as smoking, and advises patients to quit smoking and not switch. The American Heart Association stated on their website that "anyone who says e-cigarettes are safe is blowing smoke.
Researchers replicated a 2017 study by scientists at British American Tobacco (BAT), which showed that inhibition of endothelial cell migration caused by cigarette smoke, which lines the interior of the heart and blood vessels, is not caused by aerosol exposure from electronic cigarettes. "Our study again challenges the view that e-cigarettes or heated tobacco cause similar harm to combustible cigarettes," the Replica study, which used Vype ePen3, and heated tobacco products Glo Pro and IQOS 3 Duo, confirmed the results of the BAT study. It validates that transitioning to safer nicotine products can reduce harm and save lives.
An interesting fact is that switching to smoke-free products can decrease blood vessel damage and prevent the likelihood of smoking-related diseases such as atherosclerosis and high blood pressure. "Our study once again challenges the notion that e-cigarettes or heated tobacco cause similar damage to combustible cigarettes," said Dr. Massimo Caruso, lead author of the study and co-director of the replication project.
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