Study Finds Effective Methods for Smoking Cessation

Aug.30.2022
Study Finds Effective Methods for Smoking Cessation
A study found that varenicline, bupropion, and low-dose e-cigarettes were the most effective smoking cessation methods.

A study titled "Pharmacological and e-cigarette intervention for smoking cessation: systematic review, network meta-analysis, and cost-effectiveness analysis" was conducted by researchers at the University of Bristol in the UK. They searched a publication database up to March 2017 and updated their search in February 2019 with randomized clinical trials of smoking cessation interventions lasting for over six months.


The research team ultimately conducted a total of 363 experiments involving 201,045 participants. Additionally, they conducted 53 observational studies, which involved 8,783,5403 participants for safety review purposes.


After analyzing the results, the research team has concluded that the most effective treatment methods are substituting with Varencicline Standard plus Nicotine (odds ratio [OR], 3.22; 95% credible interval [CrI], 2.27-14.88), substituting with Varenicline Low plus Nicotine (OR, 5.70; 95% CrI, 1.57-21.12), and using low electronic cigarettes (OR, 3.22; 95% CrI, 0.97-12.55).


A controversial drug.


On October 1, 2021, the drug varenicline, commonly sold under the name Champix, was added to the World Health Organization's Essential Medicines List. This anti-smoking medication is well-known for helping smokers overcome cravings for cigarettes. However, despite being considered highly effective, it can also cause moderate to severe psychological side effects, ranging from terrifying nightmares to suicidal thoughts.


After multiple reports of such disturbances, the US Food and Drug Administration (FDA) issued the most severe warning for the drug, causing the sales of Valeni-cline to decrease from $846 million in 2008 to $671 million last year.


In order to overcome this decline, Pfizer, the manufacturer of the drug, has invested heavily in advertising and resolving lawsuits related to the medication. Additionally, the pharmaceutical company has released data retrieved from a study that allegedly proves that consuming Valenicline does not have a direct link to experiencing psychological disorders.


Subsequently, after refusing to lift the warning in 2014, the FDA recently decided to change their stance and abandon the warning. The agency has requested the listing of side effects associated with the drug, and has established a requirement that the label specify that varenicline is more effective than other smoking cessation therapies.


Vonnicron stock recall


Meanwhile, in June of last year, Pfizer was forced to halt distribution of Valsartan after discovering increased levels of nitrosamine in the pills and recalled some of its stock. However, in the following month, the US Food and Drug Administration announced that it would temporarily allow some manufacturers to distribute drugs containing carcinogens below a temporary limit of 185 nanograms per day until impurities could be eliminated or reduced to acceptable levels.


Disclaimer: 1. The content of this article is compiled from third-party information and is only intended for industry exchange and learning purposes. 2. This article does not represent the views of 2FIRSTS, and 2FIRSTS is unable to confirm the authenticity and accuracy of the content. The compilation of this article is only intended for industry exchange and research. 3. Due to the limitations of the compilation level, the compiled article may not express the same meaning as the original article. Please refer to the original article for accuracy. 4. For any domestic, Hong Kong, Macao, Taiwan, and foreign statements and positions, 2FIRSTS fully aligns with the Chinese government. 5. The copyright of the information compiled belongs to the original media and author. If there is any infringement, please contact us to delete it.



Disclaimer

This article is provided solely for professional research, industry discussion, and informational purposes. Any references to brands, companies, products, technologies, or policies are made for factual reporting and analytical purposes only, and do not constitute endorsement, recommendation, promotion, or advertising by 2Firsts.

Nicotine-containing products, including but not limited to cigarettes, e-cigarettes, heated tobacco products, and nicotine pouches, carry significant health risks. Readers are responsible for complying with all applicable laws and regulations in their respective jurisdictions, including age restrictions and access limitations.

The information contained in this article should not be regarded as investment, legal, medical, regulatory, or commercial advice. While 2Firsts strives to ensure the accuracy and reliability of its content, it does not assume liability for any direct or indirect loss arising from errors, omissions, inaccuracies, or reliance on the information contained herein.

This article is not intended for individuals below the legal age for accessing tobacco or nicotine-related information in their jurisdiction.

 

Copyright Notice

This article is either original content produced by 2Firsts or content reproduced, translated, summarized, or adapted from third-party sources with attribution where applicable. The intellectual property rights of the original content remain with 2Firsts or the respective original rights holders.

No individual or organization may copy, reproduce, distribute, republish, modify, translate, or otherwise use this content without prior authorization. Any unauthorized use may result in legal action.

For copyright-related inquiries, corrections, or removal requests, please contact: info@2firsts.com.

 

AI-Assisted Translation and Editing Notice

Portions of this article may have been translated, edited, or reviewed with the assistance of artificial intelligence tools to improve efficiency and readability. Due to the limitations of AI-assisted translation and editing, discrepancies, omissions, or inaccuracies may exist when compared with the original source.

Where applicable, readers are advised to refer to the original source for the most complete and accurate information. If you identify any errors or believe that any content infringes upon your rights, please contact us at info@2firsts.com, and we will review and address the matter promptly.

Moscow Police Seize About 65,000 E-Cigarettes Worth More Than RUB 30 Million
Moscow Police Seize About 65,000 E-Cigarettes Worth More Than RUB 30 Million
Russian Interior Ministry spokesperson Irina Volk said on May 6 that police in Moscow seized about 65,000 nicotine-containing products from a man during searches of residential and warehouse premises. The products were valued at about RUB 30 million, or about USD 395,727 based on an exchange rate of USD 1 = RUB 75.81.
May.11 by 2FIRSTS.ai
2Firsts Data|China Vape Exports Sink to Three-Year April Low After Tax Rebate Ends, Falling to $694 Million
2Firsts Data|China Vape Exports Sink to Three-Year April Low After Tax Rebate Ends, Falling to $694 Million
China’s e-cigarette export value declined to $694 million in April 2026, marking the lowest April level in the past three years. The data is notable because April was the first full month after China removed export VAT rebates for certain e-cigarette products. Compared with April 2025, export value fell 20.9%; compared with April 2024, it was down 22.3%. Month-on-month, exports dropped 23.2% from March 2026.
Special Report
May.23
EU Novel Tobacco Regulation Trends and Business Response | Guest Contribution by a European Legal and Compliance Expert
EU Novel Tobacco Regulation Trends and Business Response | Guest Contribution by a European Legal and Compliance Expert
Carlos Cabrera, founder of CabLab Law & Advocacy, contributes this article to 2Firsts, arguing that the EU’s evolving approach to novel tobacco regulation may unintentionally reinforce cigarette use by narrowing alternatives. He warns companies to watch signals on flavours, labelling, traceability, nicotine pouch rules and digital marketing, while grounding business decisions in realistic timelines, compliance planning and continuous monitoring.
Apr.22
Ispire and Jincheng Pharma Form Joint Venture to Enter Global High-Growth Nicotine Pouch Market
Ispire and Jincheng Pharma Form Joint Venture to Enter Global High-Growth Nicotine Pouch Market
Summary Ispire Technology announced a strategic joint venture with Chinese pharmaceutical company Jincheng Pharma to manufacture and commercialize nicotine pouch products. The partnership combines pharmaceutical-grade production capabilities with Ispire’s global regulatory infrastructure and distribution network as the company expands beyond vaping hardware into oral nicotine products.
Business
May.13
Glas Says FDA Scientific Review Backed Several Flavored Products Before Senior Leaders Blocked Them
Glas Says FDA Scientific Review Backed Several Flavored Products Before Senior Leaders Blocked Them
Glas says newly released internal FDA records show agency scientific reviewers supported authorization for several flavored G2 products before senior leadership halted them. According to documents obtained through a Freedom of Information Act request, FDA’s Office of Science first recommended marketing authorization for all eight products in December 2025 and later supported six of them in February 2026. FDA ultimately authorized only the G2 device and one tobacco-flavored pod in March.
Apr.23 by 2FIRSTS.ai
IVG Adds Six New Flavours to Pro Range, Expanding Line-Up to 39
IVG Adds Six New Flavours to Pro Range, Expanding Line-Up to 39
IVG has added six new flavours to its Pro range, taking the total line-up to 39 flavours. The new additions are Cola Frost, Rainbow Burst, Pineapple Tropic, Blueberry Raspberry, Strawberry Raspberry Ice and Raspberry Cherry Blueberry. All six are available only in 20mg nicotine strength, with an RRP of £10.95 for a starter kit and £7.95 for a refill pod.
Apr.21 by 2FIRSTS.ai