Roberto Sussman and Sebastien Soulet's Study on E-Cigarettes' Metal Content

Sep.19.2022
Roberto Sussman and Sebastien Soulet's Study on E-Cigarettes' Metal Content
Roberto Sussman and Sebastien Soulet offer a detailed assessment of the metal content in electronic cigarettes in a special edition of Toxicology journal.

Roberto Sussman and Sebastien Soulet have published a comprehensive review of 12 laboratory studies examining the metal content of e-cigarette emissions. The paper, titled "Pros and Cons of Electronic Cigarettes", appears in a special edition of the journal "Toxins".


Professor Andrzej Sobczak and Dr. Leon Kośmider wrote in the preface of a special edition that "electronic cigarettes (EC) have been present on the consumer market for over a decade, with the number of scientific publications in the PubMed database now exceeding 7,000.


Despite the large number of publications, the scientific community has not yet reached a consensus on their safety. However, it should be emphasized that comparing the amount of tobacco smoke and aerosol produced by e-cigarettes shows that the toxic compound content in aerosols is much lower than in tobacco smoke. This can be seen as a way to reduce health damage to smokers who cannot or do not want to quit using traditional methods.


They added that randomized controlled studies have shown that electronic cigarettes help with smoking cessation. The special issue covers:


Research on the chemical composition of e-cigarette liquids and vapors focuses on the impact of electronic cigarettes, snuff, and high-temperature non-combustible tobacco products on health. Studies have been conducted on the e-cigarette population, intervention research targeting youth, and smoking cessation research for adult smokers. Dr. Soulet and Dr. Sussman contributed to a paper analyzing 12 laboratory studies on the metal content of e-cigarette emissions.


Sebastien Soulet works for Ingesciences in France and Roberto Sussman works at the National Autonomous University of Mexico's Institute of Nuclear Sciences.


They wrote: "There is a legitimate concern for potential harm to users caused by the inhalation of metal compounds emitted from e-cigarette aerosol. We conducted a rigorous review of laboratory studies published after 2017 regarding the metal content in EC aerosol, with a focus on the consistency between experimental design, real-life device usage, and appropriate evaluation of exposure risk.


All experiments reporting levels of toxicological parameters for certain metals (such as nickel, lead, copper, and manganese) show the following experimental deficiencies:


The high-powered sub-ohm tank equipment, tested through an inhalation agreement, has meticulously designed airflow and suction capabilities suitable for low-powered devices. This testing inevitably involves overheating conditions conducive to the production of toxic substances and aerosols that may have a repellent effect on human users. Experimental results have shown that exposure levels were miscalculated months and years prior to the experiment, and thus corrosion effects cannot be ruled out. Critical information regarding the characteristics of the inhalation chamber and storage tank equipment, experimental methods and results, has not been disclosed, hindering the possibility of interpreting and replicating the results. Generally speaking, the metal exposure levels produced by low-powered devices that do not exhibit these deficiencies are much lower than strict toxicological reference markers.


We believe that this review provides useful guidance for a more objective assessment of the risks associated with EC aerosol emissions, and indicates the need to upgrade current laboratory testing standards.


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